Amevive should not be administered to patients infected with HIV, with a history of systemic malignancy, clinically important infection, known hypersensitivity to Amevive or any of its components, or to patients receiving other immunosuppressive agents or phototherapy.
The most serious adverse reactions in clinical trials were lymphopenia, malignancies, serious infections requiring hospitalization, and hypersensitivity reactions.
Caution should be exercised when considering the use of Amevive in patients with chronic infection, history of recurrent infection, or at high risk of malignancy. Patients should be monitored for signs and symptoms of infection during or after a course of Amevive. New infections should be closely monitored.