Amevive may provide significant improvement in your moderate-to-severe chronic plaque psoriasis. However, Amevive may not work for everyone.
It may take 8 weeks or longer to see any noticeable changes—that’s why it is important to be patient and complete the entire 12 weeks of treatment.[1-3]
In a clinical study, at 2 weeks after dosing ended:[1]
- 21% of patients saw a 75% improvement* in their psoriasis
- — Only 5% saw improvement when given placebo†
- 42% of patients saw a 50% improvement* in their psoriasis
- — In comparison, 18% saw the same results with placebo†
References
- 1. Amevive® (alefacept) prescribing information, Astellas Pharma US, Inc.
- 2. Lebwohl M, Christopher E, Langley R, et al. An international, randomized, double-blinded, placebo-controlled phase
3 trial of intramuscular alefacept in patients with chronic plaque psoriasis. Arch Dermatol. 2003;139:719-727.
- 3. Data on file, Astellas Pharma US, Inc.
- 4. Krueger GG, Papp KA, Stough DB, et al. A randomized, double-blind, placebo-controlled phase III study evaluating efficacy and
tolerability of 2 courses of alefacept in patients with chronic plaque psoriasis. J Am Acad Dermatol. 2002;47:821-833.
Amevive is approved for the treatment of moderate to severe chronic plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
Important Safety Information
-
Amevive reduces the number of certain T cells. That is part of how it is thought to treat psoriasis. This reduction could increase the
possibility of getting an infection or cancer. Before taking Amevive, be sure to tell your doctor if you have had a serious infection or
cancer. Amevive should not be taken if you are HIV positive.
-
Because Amevive reduces the number of T cells, you should have a blood test every 2 weeks during the dosing period to check your T-cell
levels. If your T-cell levels are too low, your doctor will check your blood weekly and will either postpone or stop treatment with Amevive.
-
Some patients who received Amevive in clinical studies were found to have cancers. Most of these cases were skin cancers. There were also
other types of cancer and lymphomas. Some patients developed serious infections, including wound infections and pneumonia.
-
During and after taking Amevive, if you notice anything unusual about your health or any signs of infections such
as swollen glands, fever, or chills, notify your doctor right away.
-
Amevive should not be taken if you are known to be allergic to Amevive or any of its components, since serious
allergic reactions such as hives, with or without swelling of the mouth and tongue, have been seen.
-
Some patients treated with Amevive have had serious liver injury. If your skin or the whites of your eyes become yellow, if you start to
bruise easily, or if you have persistent loss of appetite or vomiting, you should call your doctor right away.
-
Commonly reported side effects that occurred in clinical studies with Amevive included sore throat, dizziness, cough, nausea, itching,
muscle aches, chills, injection site reactions, and accidental injury.
If you become pregnant during treatment with Amevive, tell your doctor and consider enrolling in the Pregnancy Registry by calling 1-866-834-7223.
Information collected in this program is kept confidential.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit
fda.gov/medwatch or
call 1-800-FDA-1088.
Please see the full prescribing information and talk to your
doctor for more information.